Infectious Diseases

The Evolution of Viruses



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It is possible that viruses existed even before the first cellular organisms were formed. These tiny organisms are not based on cellular structures. They have a central core of a single or double strand of either DNA or RNA, covered in a protective coat of capsid protein. They are incapable of replicating independently, producing their own energy, or making proteins. They invade cells and re-program their DNA. The capsid proteins protect the genetic materials inside the virus, and control the attachment of the virus to cell receptors.

The best-known viruses are the common cold, the flu, hepatitis, and HIV. Each infected person is a study in evolution, as the viruses work frantically to reproduce while evading the immune system of the host and any anti-viral medicine the host is taking. The challenge of successful treatment is to find a way of arresting the evolutionary process long enough to kill the virus.

Viral genomes, particularly the RNA version, mutate and recombine swiftly. Natural selection can occur within the infected cell, during the spread of virus in the body, or in the transmission from host to host. Since the survival of a virus depends largely on its ability to move from host to host, natural selection favors those viruses that are better transmitted, are less susceptible to antibodies, and are persistent. The ability to produce reactions that promote excretion (coughing, sneezing, diarrhea) is also a positive evolutionary trait. Natural selection favors less virulent strains which are more likely to leave the host mobile enough to contact other potential hosts.

The great increase in human population and mobility has given the viruses the golden opportunity to produce new serotypes. Genetic reassortment and exchange of viruses between humans and animals lead to endless variations. Lineages that are unable to infect other hosts will become extinct when the host's immune system destroys the infection, or the host dies.

Because viruses constantly move genetic material from cell to cell, they may be a factor in accelerating evolution in other life forms. Once viruses find a useful protein or gene, they can transmit it to more complex species. This process is called horizontal gene transfer (HGT), which creates many more changes in cells than the occasional random mutation. This may explain why it took 2.5 billion years for evolution to move from single-celled organisms to the first multicellular life, but the it took only one billion years to evolve from there into the amazing diversity of life we see today.

"We know that the majority of the DNA in the genomes of some animal and plant species-including humans, mice, wheat and corn-came from HGT insertions," said Michael Deem, a genetic engineer at Texas' Rice University, in a press statement. "For example, we can trace the development of the adaptive immune system in humans and other jointed vertebrates to an HGT insertion about 400 million years ago. . . . I think this is the main mechanism by which dramatically new function evolves."

Viruses, with their capacity for rapid evolution, are more than microscopic menaces.. They may be essential paricipants in the genome development of our planet.

Sources and Resources
http://evolution.berkeley.edu/evolibrary/news/071201_adenovirus
evolution from a virus' point of view

http://www.jyu.fi/science/laitokset/bioenv/en/research/motu/virus
Genetics, assembly, and evolution of viruses

http://www.biology-direct.com/content/1/1/29
early evolution of viruses

http://news.nationalgeographic.com/news/2007/03/070305-evolution-germs.html
viruses may help speed up evolution

http://gsbs.utmb.edu/microbook/ch048.htm
epidemiology and evolution

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